CENTG1 antibody - middle region
Produktgrößen
25ul
£177,00
ARP52356-P050-25UL
100 ul
£412,00
ARP52356-P050-100UL
Über dieses Produkt
- SKU:
- ARP52356-P050
- Zusätzliche Namen:
- PIKE; GGAP2; CENTG1
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- CENTG1 is a GTPase-activating protein (GAP) for ARF1 and ARF5; which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins; and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells; prevents apoptosis and promotes cancer cell invasion.
- Gendetails:
- ArfGAP with GTPase domain; ankyrin repeat and PH domain 2
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human CENTG1
- Molekulargewicht:
- 90kDa
- Proteindetails:
- Arf-GAP with GTPase; ANK repeat and PH domain-containing protein 2
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php