FZR1 antibody - N-terminal region
Produktgrößen
25ul
£177,00
ARP51279-P050-25UL
100 ul
£412,00
ARP51279-P050-100UL
Über dieses Produkt
- SKU:
- ARP51279-P050
- Zusätzliche Namen:
- FZR; CDH1; FZR2; HCDH; HCDH1; CDC20C
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- FZR1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C); which confers substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis; in replacement of CDC20; and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated; leading to its dissociation from the APC/C. Following DNA damage; it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1; preventing entry into mitosis.
- Gendetails:
- Fizzy/cell division cycle 20 related 1 (Drosophila)
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human FZR1
- Molekulargewicht:
- 55kDa
- Proteindetails:
- Fizzy-related protein homolog
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php