FBXW7 Antibody - C-terminal region
Produktgrößen
25ul
£177,00
ARP47419-P050-25UL
100 ul
£412,00
ARP47419-P050-100UL
Über dieses Produkt
- SKU:
- ARP47419-P050
- Zusätzliche Namen:
- AGO; CDC4; FBW6; FBW7; hAgo; FBX30; FBXW6; SEL10; hCdc4; FBXO30; SEL-10
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- FBXW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif; the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box); which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains; Fbls containing leucine-rich repeats; and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in FBXW7 gene are detected in ovarian and breast cancer cell lines; implicating the gene's potential role in the pathogenesis of human cancers.
- Gendetails:
- F-box and WD repeat domain containing 7; E3 ubiquitin protein ligase
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human FBXW7
- Molekulargewicht:
- 80 kDa
- Proteindetails:
- F-box/WD repeat-containing protein 7
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php