FEN1 antibody - N-terminal region
Produktgrößen
25ul
£177,00
ARP46096-P050-25UL
100 ul
£412,00
ARP46096-P050-100UL
Über dieses Produkt
- SKU:
- ARP46096-P050
- Zusätzliche Namen:
- MF1; RAD2; FEN-1
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- FEN1 removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate; thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore; secondary structure can deter the protective function of this protein; leading to site-specific trinucleotide expansions.
- Gendetails:
- Flap structure-specific endonuclease 1
- Host:
- Rabbit
- Molekulargewicht:
- 42kDa
- Proteindetails:
- Flap endonuclease 1
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php