CLSTN1 antibody - N-terminal region
Produktgrößen
25ul
£177,00
ARP44580-P050-25UL
100 ul
£412,00
ARP44580-P050-100UL
Über dieses Produkt
- SKU:
- ARP44580-P050
- Zusätzliche Namen:
- CST-1; CSTN1; CDHR12; PIK3CD; ALC-ALPHA; XB31alpha; alcalpha1; alcalpha2
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP; CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion; due to the retardation of intracellular APP maturation. In complex with APBA2 and C99; a C-terminal APP fragment;CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase; most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD); most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
- Gendetails:
- Calsyntenin 1
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human CLSTN1
- Molekulargewicht:
- 110kDa
- Proteindetails:
- Calsyntenin-1
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php