GAPVD1 antibody - N-terminal region
Produktgrößen
25ul
£177,00
ARP42451-P050-25UL
100 ul
£412,00
ARP42451-P050-100UL
Über dieses Produkt
- SKU:
- ARP42451-P050
- Zusätzliche Namen:
- RAP6; GAPEX5; GAPex-5
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF); and participates in various processes such as endocytosis; insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP; leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin; it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes; retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation; it is translocated to the plasma membrane; releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation; possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
- Gendetails:
- GTPase activating protein and VPS9 domains 1
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human GAPVD1
- Molekulargewicht:
- 166kDa
- Proteindetails:
- GTPase-activating protein and VPS9 domain-containing protein 1
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php