F13B antibody - middle region
Produktgrößen
25ul
£177,00
ARP41999-P050-25UL
100 ul
£412,00
ARP41999-P050-100UL
Über dieses Produkt
- SKU:
- ARP41999-P050
- Zusätzliche Namen:
- FXIIIB
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- F13B contains 10 Sushi (CCP/SCR) domains. The B chain of factor XIII is not catalytically active; but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Defects in F13B can result in a lifelong bleeding tendency; defective wound healing; and habitual abortion.This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function; and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits; which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion; the plasma factor XIII dissociates its B subunits and yields the same active enzyme; factor XIIIa; as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules; thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency; characterized by the lack of both the A and B subunits; and type II deficiency; characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency; defective wound healing; and habitual abortion. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
- Gendetails:
- Coagulation factor XIII; B polypeptide
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human F13B
- Molekulargewicht:
- 73kDa
- Proteindetails:
- Coagulation factor XIII B chain
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php