CPSF4 antibody - C-terminal region
Produktgrößen
25ul
£177,00
ARP40675-P050-25UL
100 ul
£412,00
ARP40675-P050-100UL
Über dieses Produkt
- SKU:
- ARP40675-P050
- Zusätzliche Namen:
- NAR; NEB1; NEB-1; CPSF30
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4; an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells; the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4; 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular; and not viral; mRNAs.
- Gendetails:
- Cleavage and polyadenylation specific factor 4; 30kDa
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the C terminal region of human CPSF4
- Molekulargewicht:
- 24kDa
- Proteindetails:
- Cleavage and polyadenylation specificity factor subunit 4
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php