Foxa2 antibody - C-terminal region
Produktgrößen
25ul
£177,00
ARP37059-P050-25UL
100 ul
£412,00
ARP37059-P050-100UL
Über dieses Produkt
- SKU:
- ARP37059-P050
- Zusätzliche Namen:
- Hnf3; Hnf-3; Hnf3b; Tcf3b; HNF3be; Hnf-3b; Tcf-3b; HNF3-be; HNF3beta; HNF3-beta
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Foxa2 is a transcription factor that is involved in embryonic development; establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Foxa2 is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. In embryonic development Foxa2 is required for notochord formation. Foxa2 is involved in the development of multiple endoderm-derived organ systems such as the liver; pancreas and lungs; Foxa1 and Foxa2 seem to have at least in part redundant roles. Foxa2 modulates the transcriptional activity of nuclear hormone receptors; inhibits AR-mediated transcription from the LCN5 promoter. Foxa2 binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. Foxa2 interacts with the cis-acting regulatory regions of these genes. Foxa2 is involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Foxa2 is involved in regulation of fat metabolism; activates transcriptional programs of lipid metabolism and ketogenesis at low insulin state.
- Gendetails:
- Forkhead box A2
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide corresponding to a region of Mouse
- Molekulargewicht:
- 48kDa
- Proteindetails:
- Hepatocyte nuclear factor 3-beta
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php