Dnmt1 antibody - N-terminal region
Produktgrößen
25ul
£177,00
ARP37033-P050-25UL
100 ul
£412,00
ARP37033-P050-100UL
Über dieses Produkt
- SKU:
- ARP37033-P050
- Zusätzliche Namen:
- MTa; Dnmt; MCMT; Met1; Cxxc9; MTase; Met-1; Dnmt1o; MommeD; m.MmuI; MommeD2
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Dnmt1 methylates CpG residues.Dnmt1 preferentially methylates hemimethylated DNA. Dnmt1 associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand; that is essential for epigenetic inheritance.Dnmt1 associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones.Dnmt1 mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS; Dnmt1 is involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
- Gendetails:
- DNA methyltransferase (cytosine-5) 1
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of mouse Dnmt1
- Molekulargewicht:
- 183kDa
- Proteindetails:
- DNA (cytosine-5)-methyltransferase 1
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php