Eed antibody - N-terminal region
Produktgrößen
25ul
£177,00
ARP35696-P050-25UL
100 ul
£412,00
ARP35696-P050-100UL
Über dieses Produkt
- SKU:
- ARP35696-P050
- Zusätzliche Namen:
- l7; l(7); lusk; l7Rn5; l(7)5Rn
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Eed is a polycomb group (PcG) protein. It is a component of the PRC2/EED-EZH2 complex; which methylates 'Lys-9' and 'Lys-27' of histone H3; leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases; thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXA7; HOXB6 and HOXC8. Eed plays a role in X chromosome inactivation (XCI); in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Eed is required for stable maintenance of XCI in both embryonic and extra-embryonic tissues. Eed may prevent transcriptional activation of facultative heterochromatin during differentiation. Eed is required for development of secondary trophoblast giant cells during placental development. Eed may regulate hippocampal synaptic plasticity in the developing brain.
- Gendetails:
- Embryonic ectoderm development
- Host:
- Rabbit
- Molekulargewicht:
- 50kDa
- Proteindetails:
- Polycomb protein EED
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php