COPS2 antibody - N-terminal region
Produktgrößen
25ul
£177,00
ARP34188-P050-25UL
100 ul
£412,00
ARP34188-P050-100UL
Über dieses Produkt
- SKU:
- ARP34188-P050
- Zusätzliche Namen:
- CSN2; SGN2; ALIEN; TRIP15
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- COPS2 is an essential component of the COP9 signalosome complex (CSN). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes; leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF; CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53; c-jun/JUN; IkappaBalpha/NFKBIA; ITPK1 and IRF8/ICSBP; possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system; respectively. COPS2 is involved in early stage of neuronal differentiation via its interaction with NIF3L1.
- Gendetails:
- COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human COPS2
- Molekulargewicht:
- 52kDa
- Proteindetails:
- COP9 signalosome complex subunit 2
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php