CLDN16 antibody - C-terminal region
Produktgrößen
25ul
£177,00
ARP33632-P050-25UL
100 ul
£412,00
ARP33632-P050-100UL
Über dieses Produkt
- SKU:
- ARP33632-P050
- Zusätzliche Namen:
- HOMG3; PCLN1
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets; forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet; with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-16; a member of the claudin family; is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys; specifically in the thick ascending limb of Henle; where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in the corresponding gene are a cause of primary hypomagnesemia; which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria; resulting in nephrocalcinosis and renal failure.Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets; forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet; with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene; a member of the claudin family; is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys; specifically in the thick ascending limb of Henle; where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia; which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria; resulting in nephrocalcinosis and renal failure. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
- Gendetails:
- Claudin 16
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the C terminal region of human CLDN16
- Molekulargewicht:
- 34kDa
- Proteindetails:
- Claudin-16
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php