CDKN1A Antibody - N-terminal region
Produktgrößen
25ul
£177,00
ARP30198-P050-25UL
100 ul
£412,00
ARP30198-P050-100UL
Über dieses Produkt
- SKU:
- ARP30198-P050
- Zusätzliche Namen:
- P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes; and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53; through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA); a DNA polymerase accessory factor; and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases; which thus leads to a dramatic activation of CDK2; and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
- Gendetails:
- cyclin-dependent kinase inhibitor 1A (p21; Cip1)
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human CDKN1A
- Molekulargewicht:
- 18kDa
- Proteindetails:
- Cyclin-dependent kinase inhibitor 1
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php