Chylomicrons
Produktgrößen
1 mg
12-16-030825-1MG
5 mg
12-16-030825-5MG
Über dieses Produkt
- SKU:
- 12-16-030825
- Zusätzliche Namen:
- CHY|Lipid Metabolism, Cardiovascular Disease
- Buffer:
- Liquid in 150 mM NaCl, pH 7.4, and 0.01% EDTA
- CE/IVD:
- RUO
- Weitere Details:
- Chylomicrons are enterocyte-derived triglyceride-rich lipoproteins that transport dietary lipids from the intestine to peripheral tissues and the liver. These particles (~75-1,200 nm diameter) consist of a hydrophobic core of triglycerides (85-92%) and cholesterol esters, surrounded by a phospholipid monolayer containing apolipoproteins. ApoB-48, synthesized exclusively in the intestine through mRNA editing of the APOB gene, serves as the structural scaffold for chylomicron assembly. During circulation, chylomicrons acquire apoE and apoC-II from HDL, with the latter activating lipoprotein lipase (LPL) to hydrolyze triglycerides into free fatty acids for tissue uptake. Post-lipolysis remnants, enriched in cholesterol and apoE, are cleared by hepatic receptors (LDL-R, LRP1). Familial chylomicronemia syndrome caused by LPL deficiency or mutations in cofactors (apoC-II, GPIHBP1), leading to severe hypertriglyceridemia (>2,000 mg/dL) and pancreatitis risk. Chylomicron retention disease (CRD), an autosomal recessive SAR1B mutations impair chylomicron secretion, causing vitamin E deficiency, neuropathy, and growth failure. Postprandial chylomicron remnants contribute to atherosclerosis via endothelial dysfunction and proinflammatory pathways. Quantifying apoB-48 provides a specific biomarker for intestinal lipoprotein metabolism, aiding cardiovascular risk stratification.
- Formulierung:
- Liquid in 150 mM NaCl, pH 7.4, and 0.01% EDTA
- Molekulargewicht:
- 50,000-1,000,000 Da
- Physischer Zustand:
- Liquid
- Reinheit:
- Essentially free of other plasma lipoproteins as determined SPIFE Vis Cholesterol gel kit. ≥95%
- Aufreinigung:
- Liquid Chromatography Methods
- Versandbedingungen:
- Blue Ice
- Quelle:
- Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
- Lagerbedingungen:
- Please refer to datasheet
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
