Epcoritamab ELISA Kit
Produktgrößen
96 tests
£1373,00
KDC90703-96TESTS
Über dieses Produkt
- SKU:
- KDC90703
- Zusätzliche Namen:
- GEN3013, CAS: 2134641-34-0
- Anwendung:
- ELISA
- Weitere Details:
- Epcoritamab (DuoBody-CD3xCD20, GEN3013) is a novel bispecific IgG1 antibody redirecting T-cells toward CD20+ tumor cells. Here, we assessed the preclinical efficacy of epcoritamab against primary tumor cells present in the lymph node biopsies from newly diagnosed (ND) and relapsed/refractory (RR) B-NHL patients. In the presence of T-cells from a healthy donor, epcoritamab demonstrated potent activity against primary tumor cells, irrespective of prior treatments, including CD20 mAbs. Median lysis of 65, 74, and 84% were achieved in diffuse large B-cell lymphoma (n = 16), follicular lymphoma (n = 15), and mantle cell lymphoma (n = 8), respectively. Furthermore, in this allogeneic setting, we discovered that the capacity of B-cell tumors to activate T-cells was heterogeneous and showed an inverse association with their surface expression levels of the immune checkpoint molecule Herpesvirus Entry Mediator (HVEM). In the autologous setting, when lymph node (LN)-residing T-cells were the only source of effector cells, the epcoritamab-dependent cytotoxicity strongly correlated with local effector cell-to-target cell ratios. Further analyses revealed that LN-residing-derived or peripheral blood-derived T-cells of B-NHL patients, as well as heathy donor T-cells equally mediated epcoritamab-dependent cytotoxicity. These results show the promise of epcoritamab for treatment of newly-diagnosed or relapsed/refractory B-NHL patients, including those who became refractory to previous CD20-directed therapies.
- Format:
- Colorimetric
- Immunogen:
- Epcoritamab
- Physischer Zustand:
- Plasma, Serum
- Reichweite:
- 0.31-5 ug/mL
- Empfindlichkeit:
- 0.156 ug/ml
- Versandbedingungen:
- Blue Ice
- Hersteller:
- AntibodySystem
- Typ:
- Assay Kits: ELISAs