Recombinant Human BP180/NC16a Protein
Produktgrößen
50 ug
£168,00
AID00701-50UG
100 ug
£327,00
AID00701-100UG
1 mg
£1145,00
AID00701-1MG
Über dieses Produkt
- SKU:
- AID00701
- Zusätzliche Namen:
- LinearIgAdiseaseantigen1,COL17A1,180kDabullouspemphigoidantigen2,LAD-1,LinearIgAbullousdiseaseantigenof97kDa,120kDalinearIgAdermatosisantigen,97-LAD,Collagenalpha-1(XVII)chain,Bullouspemphigoidantigen2,97kDalinearIgAbullousdermatosisantigen,LABD97,97kDaLADantigen,BPAG2,BP180
- Buffer:
- LyophilizedfromasolutioninPBSpH7.4,0.02%NLS,1mMEDTA,4%Trehalose,1%Mannitol.
- Weitere Details:
- BullouspemphigoidistheresultofanattackonthebasementmembraneoftheepidermisbyIgG+/-IgEimmunoglobulins(antibodies)andactivatedTlymphocytes(whitebloodcells).ThetargetistheproteinBP180(alsocalledTypeXVIIcollagen),orlessfrequentlyBP230(aplakin).TheseproteinsarewithintheNC16AdomainofcollagenXVII.Theyareassociatedwiththehemidesmosomes,structuresthatensuretheepidermalkeratinocytecellssticktothedermistomakeawaterproofseal.ThebindingoftheautoantibodiestotheproteinsandreleaseofcytokinesfromtheTcellsleadtocomplementactivation,recruitmentofneutrophils(acuteinflammatorycells)andthereleaseofproteolyticenzymes.Thesedestroythehemidesmosomesandcausetheformationofsubepidermalblisters.
- Physischer Zustand:
- Lyophilized
- Reinheit:
- >95% as determined by sds-page.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- -70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Hersteller:
- AntibodySystem
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins