Monoclonal Anti-SN38 Antibody, Mouse IgG1
Produktgrößen
100 ug
£630,00
SN8-M685-100UG
1 mg
£4234,00
SN8-M685-1MG
Über dieses Produkt
- SKU:
- SN8-M685
- Anwendung:
- ELISA, Immunoassay
- Buffer:
- PBS (pH 7.4)
- Klonalität:
- Monoclonal
- Weitere Details:
- SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold. SN38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolism of SN-38 predicts irinotecan toxicity, as it is then less easily excreted from the body in its SN-38 glucuronide form. SN-38 and its glucuronide are lost into the bile and intestines. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered irinotecan.
- Immunogen:
- SN38
- Physischer Zustand:
- Powder
- Aufreinigung:
- 90%
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ACRO Biosystems
- Typ:
- Antibody: Monoclonal Antibody
