Anti-Human IL-15 (12B11E5) monoclonal antibody, Mouse IgG1 (MALS verified)
Produktgrößen
100 ug
£318,00
IL5-M542-100UG
1 mg
£2108,00
IL5-M542-1MG
Über dieses Produkt
- SKU:
- IL5-M542
- Anwendung:
- ELISA
- Buffer:
- PBS (pH 7.4)
- Klonalität:
- Monoclonal
- Weitere Details:
- Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.
- Immunogen:
- IL-15
- Physischer Zustand:
- Powder
- Aufreinigung:
- 0.9
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ACRO Biosystems
- Typ:
- Antibody: Monoclonal Antibody
