NY-ESO-1 specific TCR-HEK293 cell line
Produktgrößen
2 vials
£7218,00
CHEK-STP114-2VIALS
Über dieses Produkt
- SKU:
- CHEK-STP114
- Anwendung:
- Cell-based/Functional Assay, ELISA, FACS
- Weitere Details:
- Cluster of Differentiation 3 (CD3) is a pivotal multimeric T cell co-receptor complex essential for adaptive immune responses. Composed of epsilon (E Epsilon), gamma (G Gamma), delta (D Delta), and zeta (Z Zeta) polypeptide chains forming three distinct dimers (E EpsilonG Gamma, E EpsilonD Delta, Z ZetaZ Zeta), CD3 non-covalently associates with the T-cell receptor (TCR) to establish the critical TCR/CD3 receptor complex on T cell surfaces. Structurally, CD3 proteins belong to the immunoglobulin superfamily, featuring a transmembrane domain, an N-terminal extracellular region with immunoglobulin-like domains, and cytoplasmic tails embedded with immunoreceptor tyrosine-based activation motifs (ITAMs). These ITAMs are fundamental for initiating signal transduction upon T cell receptor engagement, thereby activating both CD4+ T helper and CD8+ cytotoxic T cells. As a defining marker of the T cell lineage, CD3's central role in T cell activation makes its modulation, via stimulating or blocking antibodies, a promising therapeutic avenue for conditions like organ transplant rejection and autoimmune diseases.
- Immunogen:
- NY-ESO-1
- Physischer Zustand:
- Liquid
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Liquid N2
- Hersteller:
- ACRO Biosystems
- Typ:
- Cells: Cell Lines
- Shipping Charges:
- This product has high associated shipping charges