ACE2 (human) ELISA Kit
Produktgrößen
1 x 96 Tests
£678,00
90-7008-96T
Über dieses Produkt
- SKU:
- 90-7008
- Zusätzliche Namen:
- SARS-CoV-2 Receptor; Angiotensin-converting Enzyme 2; Angiotensin-converting Enzyme Homolog; Angiotensin-converting Enzyme-related Carboxypeptidase; Metalloprotease MPROT15
- Weitere Details:
- Detects human ACE2 in serum; plasma; urine and cell culture supernatant.Human ACE2 gene; localized in X chromosome; encodes for a 805 amino acid protein with an N-terminal signal sequence; a metalloprotease zinc binding site (HEMGH) and a hydrophobic region near the C-terminus acting as a membrane anchor (transmembrane domain). Angiotensin-converting enzyme 2 (ACE2) is a type I transmembrane metallocarboxypeptidase within the renin-angiotensin system (RAS); which plays a key role in blood pressure regulation; fluid and electrolyte balance; thirst; cardiac/renal function and growth. ACE2 is expressed on the cell surface of type 2 alveolar epithelial cells in the lungs as well as on cells in many other tissues. ACE2 shares approximately 60% homology with ACE; the other key enzyme of the RAS system. ACE2 converts angiotensin II (Ang II) into Ang (1-7); which acts on the Mas receptor and plays a role in cardiovascular disease to lower blood pressure through vasodilation and by promoting kidney sodium and water excretion; but also to lower inflammation. The effects of ACE2 directly oppose those induced by ACE-Ang II signaling; whereby ACE converts Ang I into Ang II; which increases blood pressure by inducing vasoconstriction; increasing kidney reabsorption of sodium and water and promoting inflammation. ACE2 has been identified as a key receptor on target cells for SARS-CoV infections in 2002. ACE2 functions as the entry receptor of the new SARS-CoV-2 coronavirus that emerged in China in 2019 and is the cause of the new disease COVID-19. Strong binding of the spike protein of SARS-CoV-2 to ACE2; along with proteolytic cleavage of ACE2 by transmembrane serine protease 2 (TMPRSS2); facilitates entry of the virus into cells; viral replication and cell-to-cell transmission. ACE2 can undergo an ADAM17 (a disintegrin and metalloproteinase 17)-mediate "shedding" from endothelial cells; resulting in the release of the ectodomain into the circulation. This soluble form may act as a competitive interceptor of SARS-CoV-2 and other coronaviruses by preventing binding of the viral particle to the surface-bound; full-length ACE2. Soluble ACE2 might also be used as biomarker of hypertension and cardiovascular diseases.
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 12 months after the day of manufacturing. See expiry date on ELISA Kit box.
- Hersteller:
- Abeomics
- Typ:
- Assay Kits:ELISAs
- Datenblatt des Herstellers:1.jpg