Monoclonal Antibody to TRIM29 (Lung Squamous Cell Carcinoma Marker)(Clone : MSVA-629M)
Produktgrößen
20ug
£458,00
36-3826-20UG
100ug
£716,00
36-3826-100UG
Über dieses Produkt
- SKU:
- 36-3826
- Anwendung:
- IHC-Frozen
- translate.label.attr.clone:
- MSVA-629M
- Klonalität:
- Monoclonal
- Weitere Details:
- It recognizes a 66kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies. It plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
- Gendetails:
- TRIM29
- Host:
- Mouse
- Isotyp:
- IgG2b / Kappa
- Aufreinigung:
- Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide.
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg