Anti-MECA-79 Monoclonal Antibody(Clone: MECA-79)
Produktgrößen
20 µg
£397,00
36-3815-20UG
100 µg
£716,00
36-3815-100UG
Über dieses Produkt
- SKU:
- 36-3815
- Zusätzliche Namen:
- MECA-79; Peripheral Node Addressin (PNAd)
- translate.label.attr.clone:
- MECA-79
- Klonalität:
- Monoclonal
- Weitere Details:
- MECA-79 recognizes a carbohydrate epitope shared with a group of sulfation decorated sialomucins; including sulfated ligands for CD62L (CD34; GlyCAM-1; Sgp200; and a subset of MAdCAM-1). This set antigens has been referred to as peripheral node addressin (PNAd) with the molecular mass 50-250 kD. It has been identified that GlcNAc-6-SO4 sulfation contributes to MECA-79 binding and the core 1 beta1;3-N-acetylglucosaminyltransferase is required for the generation of the MECA-79 epitope. MECA-79 is expressed on high endothelial venules (HEV) of lymphoid tissues; chronic inflamed tissues and rheumatoid synovia. The interaction of PNAd with CD62L receptor is involved in tethering and rolling of lymphocytes along HEV in lymphoid tissues. MECA-79 antibody reacts with Mouse; human and many other species PNAd and blocks L-selectin-dependent lymphocyte adhesion in vitro and in vivo.
- Host:
- Rat
- Immunogen:
- Mouse lymph node stromal cells
- Isotyp:
- Rat IgM; kappa
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php