Anti-CDw17 (Lactosylceramide or LacCer) Monoclonal Antibody(Clone: HO18.3G-6.F5)
Produktgrößen
20 µg
£397,00
36-3740-20UG
100 µg
£716,00
36-3740-100UG
Über dieses Produkt
- SKU:
- 36-3740
- Zusätzliche Namen:
- Lactosylceramide; LacCer; β-D-galactosyl-(1-4)-β-D-glucosyl-(1-1')-ceramide;CDw17
- translate.label.attr.clone:
- HO18.3G-6.F5
- Klonalität:
- Monoclonal
- Weitere Details:
- CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes; granulocytes; basophils; platelets; a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17; which can then mediate signaling toward PECAM-1 expression and angiogenesis. Tumor necrosis factor )-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization.
- Host:
- Mouse
- Immunogen:
- β-2 Microglobulin associated proteins from a detergent lysate of human PBL
- Isotyp:
- Mouse IgM; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php