Anti-Cig2 Monoclonal Antibody(Clone: 3A11/5)
Produktgrößen
20 µg
£397,00
36-3714-20UG
100 µg
£716,00
36-3714-100UG
Über dieses Produkt
- SKU:
- 36-3714
- Zusätzliche Namen:
- B type S phase cyclin antibody
- translate.label.attr.clone:
- 3A11/5
- Klonalität:
- Monoclonal
- Weitere Details:
- Cig2 is a cyclin that functions as the catalytic subunit of cyclin-dependent kinases (Cdks) in the fission yeast Schizosaccharomyces pombe. It is a B-type; S phase cyclin that is required for both the G1/S and G2/M cell cycle transitions and is expressed in a sharp spike that peaks during the G1/S period. Cig2 binds to Cdc2 (Cdk); and the resulting Cdc2/Cig2 complex controls the G1/S transition of the cell cycle. Disruption of Cig2 delays the onset of mitosis. The expression of the Cig2 gene is dependent on Mlu1-binding factor (MBF); and the protein is destroyed during anaphase by the APC/cyclosome (APC/C) and Skp1/Cullin-1/F-box (SCF); thereby ensuring the spike expression pattern of Cig2. SCF regulates Cig2 levels in a dual manner; transcriptionally and post-translationally; while APC/C only destroys the protein.
- Host:
- Mouse
- Immunogen:
- Bacterial S. pombe Cig2 Purified protein.
- Isotyp:
- Mouse IgG1; kappa
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php