Anti-E-Cadherin / CD324 (Intercellular Junction Marker) Monoclonal Antibody(Clone: SPM471)
Produktgrößen
20 µg
£397,00
36-3680-20UG
100 µg
£716,00
36-3680-100UG
Über dieses Produkt
- SKU:
- 36-3680
- Zusätzliche Namen:
- Arc 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD324; CDH1; CDHE; E-Cad/CTF3; E-cadherin; ECAD; Epithelial cadherin; epithelial calcium dependent adhesion protein; Liver cell adhesion molecule (LCAM); Uvomorulin (UVO)
- translate.label.attr.clone:
- SPM471
- Klonalität:
- Monoclonal
- Weitere Details:
- Recognizes a protein of 120-80kDa; identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins; E-; N- and P-cadherin; consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins; such as -catenin; to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer; prostate and esophageal cancer. In combination with p120 Catenin; it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.
- Host:
- Mouse
- Immunogen:
- Recombinant human E-Cadherin protein
- Isotyp:
- Mouse IgG1; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
