Anti-CD40 Ligand / CD154 / TRAP1 (Activation Marker of T-Lymphocytes) Monoclonal Antibody(Clone: CD40LG/2761)
Produktgrößen
20 µg
£397,00
36-3609-20UG
100 µg
£716,00
36-3609-100UG
Über dieses Produkt
- SKU:
- 36-3609
- Zusätzliche Namen:
- CD154; gp39; hCD40L; HIGM1; IGM; IMD3; T B cell activating molecule; T BAM; T-cell antigen Gp39; TNF-alphaelated activation protein; TrAP; Tumor necrosis factor ligand superfamily member 5 (TNFSF5)
- translate.label.attr.clone:
- CD40LG/2761
- Klonalität:
- Monoclonal
- Weitere Details:
- CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells; macrophages; and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response throµgh the activation of dendritic cells and the induction of interleukin-12 production. For example; engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1; VCAM-1; and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines; chemokines; NO; and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation; proliferation; immunoglobulin (Ig) isotype switching; and formation of memory B cells.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 108-261) of human CD40LG protein (exact sequence is proprietary)
- Isotyp:
- Mouse IgG2b; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
