Anti-Aurora B (Proliferation Marker) Monoclonal Antibody(Clone: AURKB/1593)
Produktgrößen
20 µg
£397,00
36-3499-20UG
100 µg
£716,00
36-3499-100UG
Über dieses Produkt
- SKU:
- 36-3499
- Zusätzliche Namen:
- AIK2; AIM-1; ARK-2; AurB; AURKB; Aurora-1; Aurora and Ipl1 like midbody associated protein 1; Aurora kinase B; Aurora-B; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; IPL1; Protein phosphatase 1 regulatory subunit 48 (PPP1R48); Serine/threonine-protein kinase 12; Serine/threonine-protein ki
- translate.label.attr.clone:
- AURKB/1593
- Klonalität:
- Monoclonal
- Weitere Details:
- Recognizes a protein of 39kDa; which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation; cytokinesis; protein localization to the centromere and kinetochore; correct microtubule-kinetochore attachment; and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma; astrocytoma; seminoma and carcinomas of the colon; prostate; endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 89-251) of human Aurora B protein (exact sequence is proprietary)
- Isotyp:
- Mouse IgG1; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
