Anti-TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) Monoclonal Antibody(Clone: HAVCR2/192)
Produktgrößen
20 µg
£397,00
36-3421-20UG
100 µg
£716,00
36-3421-100UG
Über dieses Produkt
- SKU:
- 36-3421
- Zusätzliche Namen:
- CD366; HAVR2; Hepatitis A virus cellular receptor 2 (HAVCR2); Kidney injury molecule 3 (KIM3); T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM3; TIMD3
- translate.label.attr.clone:
- HAVCR2/192
- Klonalität:
- Monoclonal
- Weitere Details:
- TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4+ Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2). In chronic inflammation; autoimmune disorders; and some cancers; TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production; Th1 cell proliferation and cytotoxicity; regulatory T cell development; and increases in macrophage and neutrophil infiltration into sites of inflammation.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human TIM3 protein (around aa 22-202) (exact sequence is proprietary)
- Isotyp:
- Mouse IgG1; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg