Anti-PD-L2 / PDCD1LG2 / CD273 Monoclonal Antibody(Clone: PDL2/1850)
Produktgrößen
20 µg
£397,00
36-3404-20UG
100 µg
£716,00
36-3404-100UG
Über dieses Produkt
- SKU:
- 36-3404
- Zusätzliche Namen:
- B7 dendritic cell molecule; B7-DC; B7DC; Btdc; Butyrophilin B7DC; CD273; PD-L2; PDCD1L2; PDCD1LG2; PDL2; Programmed death ligand 2
- translate.label.attr.clone:
- PDL2/1850
- Klonalität:
- Monoclonal
- Weitere Details:
- Recognizes a protein of about 31kDa; which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation; cytokine production; differentiation of effector T cells and the induction of Bcl-x; a promoter of T cell survival. Conversely; engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28; cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart; lung and kidney sµggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 27-220) of human PD-L2 protein (exact sequence is proprietary)
- Isotyp:
- Mouse IgG1; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
