Anti-p53 Tumor Suppressor Protein Monoclonal Antibody(Clone: DO-1)
Produktgrößen
20 µg
£397,00
36-3297-20UG
100 µg
£716,00
36-3297-100UG
Über dieses Produkt
- SKU:
- 36-3297
- Zusätzliche Namen:
- Antigen NY-CO-13; BCC7; Cellular Tumor Antigen p53; LFS1; TP53; Transformation Related Protein 53 (TRP53); Tumor Protein p53; Tumor Suppressor p53
- translate.label.attr.clone:
- DO-1
- Klonalität:
- Monoclonal
- Weitere Details:
- Recognizes a 53kDa protein; which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 20-25) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth; replication; and apoptosis. It binds to MDM2; SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma; lung carcinoma; colorectal; and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors; including breast; ovarian; bladder; colon; lung; and melanoma.
- Host:
- Mouse
- Immunogen:
- Recombinant human wild type p53 protein expressed in E. coli.
- Isotyp:
- Mouse IgG2a; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
