Anti-STAT5B Monoclonal Antibody(Clone: STAT5B/2611)
Produktgrößen
20 µg
£397,00
36-3219-20UG
100 µg
£716,00
36-3219-100UG
Über dieses Produkt
- SKU:
- 36-3219
- Zusätzliche Namen:
- Signal transducer and activator of transcription 5B; STAT5; Stat5b; Transcription factor STAT5B
- translate.label.attr.clone:
- STAT5B/2611
- Klonalität:
- Monoclonal
- Weitere Details:
- Signal transducer and activator of transcription 5A (Stat5a) and Stat5b; which share 96% homology; undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors; and then form homo- or heterodimers that translocate to the nucleus; where they initiate transcription. Activation of Stat5a via IL-2; IL-3; IL-7/ GM-CSF; erythropoietin; thrombopoietin and growth hormones influences proliferation; differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2; IL-4; CSF-1 and growth hormones influences TCR signaling; apoptosis; adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human STAT5B protein
- Isotyp:
- Mouse IgG1; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
