Anti-BRCA1 (Breast Marker) Monoclonal Antibody(Clone: BRCA1/1398)
Produktgrößen
20 µg
£397,00
36-3208-20UG
100 µg
£716,00
36-3208-100UG
Über dieses Produkt
- SKU:
- 36-3208
- Zusätzliche Namen:
- BRCA1; Breast and ovarian cancer susceptibility protein 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; BROVCA1; IRIS; PNCA4; PPP1R53; Protein phosphatase 1 regulatory subunit 53; PSCP; RING finger protein 53; RNF53
- translate.label.attr.clone:
- BRCA1/1398
- Klonalität:
- Monoclonal
- Weitere Details:
- This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability; and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors; DNA damage sensors; and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II; and throµgh the C-terminal domain; also interacts with histone deacetylase complexes. This protein thus plays a role in transcription; DNA repair of double-stranded breaks; and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
- Host:
- Mouse
- Immunogen:
- Recombinant human BRCA1 protein fragment (around aa445-620) (exact sequence is proprietary)
- Isotyp:
- Mouse IgG1; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
