Anti-Spastin Monoclonal Antibody(Clone: Sp 6C6)
Produktgrößen
20 µg
£397,00
36-3185-20UG
100 µg
£716,00
36-3185-100UG
Über dieses Produkt
- SKU:
- 36-3185
- Zusätzliche Namen:
- ADPSP; FSP2; Spast; Spatin; SPG4
- translate.label.attr.clone:
- Sp 6C6
- Klonalität:
- Monoclonal
- Weitere Details:
- The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility; membrane trafficking; proteolysis; protein folding and organelle biogenesis. Spastin; a member of the AAA protein family; is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm; where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST; SPG4) cause the most common form of spastic paraplegia 4; an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent; retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40% of all autosomal dominant HSPs.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human Spastin protein.
- Isotyp:
- Mouse IgG2a; kappa
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
