Anti-Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) Monoclonal Antibody(Clone: SOD1/2089)
Produktgrößen
20 µg
£397,00
36-3165-20UG
100 µg
£716,00
36-3165-100UG
Über dieses Produkt
- SKU:
- 36-3165
- Zusätzliche Namen:
- Amyotrophic lateral sclerosis 1 (ALS1); Cu/Zn SOD; Cu/Zn Superoxide Dismutase; Epididymis Secretory Protein Li 44; Indophenoloxidase A (IPOA); Superoxide Dismutase [Cu-Zn]; Superoxide Dismutase 1 (SOD1)
- translate.label.attr.clone:
- SOD1/2089
- Klonalität:
- Monoclonal
- Weitere Details:
- Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically; SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions; which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases; including amyotrophic lateral sclerosis (ALS); a neurodegenerative disease characterized by the loss of spinal motor neurons; Down syndrome and Alzheimer's disease. In familial ALS; several mutations in SOD-1 predominate; resulting in the loss of zinc binding; the loss of scavenging activity of SOD-1; and correlate with an increase in neurotoxicity and motor neuron death.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human SOD1 protein
- Isotyp:
- Mouse IgG2b; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
