Anti-VISTA / GI24 (Negative Regulator of Immune Response) Monoclonal Antibody(Clone: VISTA/2865)
Produktgrößen
20 µg
£397,00
36-3147-20UG
100 µg
£716,00
36-3147-100UG
Über dieses Produkt
- SKU:
- 36-3147
- Zusätzliche Namen:
- B7H5; DD1alpha; GI24; PD-1H; PDCD1 homolog; Platelet receptor Gi24; PP2135; Stress-induced secreted protein 1 (SISP1); V domain Ig suppressor of T cell activation; V Set Immuno-regulatory Receptor
- translate.label.attr.clone:
- VISTA/2865
- Klonalität:
- Monoclonal
- Weitere Details:
- VISTA / GI24 is a transmembrane protein expressed in bone; on embryonic stem cells (ESCs); and on tumor cell surfaces. On ESC s; Gi24 appears to positively interact with BMP-4; potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells; Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162aa extracellular region with one V-type Ig-like domain and a 96aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP; generating a soluble 30kDa extracellular fragment plus a 25-30kDa membrane-bound fragment. VISTA is a negative checkpoint regulator and is expressed on myeloid cells; T-cells and human TILs (tumor infiltrating lymphocytes) on MDSCs (myeloid-derived suppressor cells) in the TME (tumor microenvironment). It is very likely both a ligand and receptor and is a promising target for cancer immunotherapy.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human VISTA protein
- Isotyp:
- Mouse IgG2a; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
