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Antikörper

Anti-Bcl-6 (Follicular Lymphoma Marker) Monoclonal Antibody(Clone: BCL6/1527)

Produktgrößen
20 µg
£397,00
36-3109-20UG
100 µg
£716,00
36-3109-100UG
Über dieses Produkt
SKU:
36-3109
Zusätzliche Namen:
B-cell lymphoma 5 protein; B-Cell Lymphoma 6 Protein; BCL5; BCL6; BCL6A; cys his2 zinc finger transcription factor; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor
translate.label.attr.clone:
BCL6/1527
Klonalität:
Monoclonal
Weitere Details:
The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array; containing more than 19;000; full-length human proteins. Recognizes a protein of 95kDa; which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL); where CD10; bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large () cells of NLPHL are bcl-6 positive. In contrast; anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Host:
Mouse
Immunogen:
Recombinant human bcl-6 protein fragment (around aa256-389) (Exact sequence is proprietary)
Isotyp:
Mouse IgG1; kappa
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig. 2: Formalin-fixed; paraffin-embedded human Follicular Lymphoma stained with BCL-6 Mouse Monoclonal Antibody (BCL6/1527).
Fig. 3: Formalin-fixed; paraffin-embedded human Hodgkin's Lymphoma stained with BCL-6 Mouse Monoclonal Antibody (BCL6/1527).
Fig. 4: SDS-PAGE Analysis Purified BCL-6 Mouse Monoclonal Antibody (BCL6/1527). Confirmation of Integrity and Purity of Antibody.
Fig. 4: SDS-PAGE Analysis Purified BCL-6 Mouse Monoclonal Antibody (BCL6/1527). Confirmation of Integrity and Purity of Antibody.
Fig. 5: Analysis of Protein Array containing more than 19;000 full-length human proteins using bcl-6 Mouse Monoclonal Antibody (BCL6/1527) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array