Anti-Calcineurin A / PPP3CA Monoclonal Antibody(Clone: BF1.1)
Produktgrößen
20 µg
£397,00
36-2993-20UG
100 µg
£716,00
36-2993-100UG
Über dieses Produkt
- SKU:
- 36-2993
- Zusätzliche Namen:
- Calcineurin A alpha; Calcineurin A1; Calcineurin A; Calmodulin-dependent calcineurin A subunit alpha isoform; CALN; CALNA1; CAM-PRP catalytic subunit; CCN1; CNA alpha; CNA1; Ppp3ca; Protein phosphatase 2B catalytic subunit (PPP2B); Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform
- translate.label.attr.clone:
- BF1.1
- Klonalität:
- Monoclonal
- Weitere Details:
- Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues; but its levels are highest in the brain; where it may play a role in learning and memory. It has many substrates; including NFAT; a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length Calcineurin A protein
- Isotyp:
- Mouse IgG1; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php