Anti-SMAD4 (Pancreatic Adenocarcinoma Marker) Monoclonal Antibody(Clone: SMAD4/2524)
Produktgrößen
20 µg
£397,00
36-2737-20UG
100 µg
£716,00
36-2737-100UG
Über dieses Produkt
- SKU:
- 36-2737
- Zusätzliche Namen:
- Deleted in Pancreatic Carcinoma 4 (DPC4); JIP; MAD homolog 4 (MADH4); Mothers against decapentaplegic homolog 4 (MADH4); Mothers against DPP homolog 4; MYHRS; SMAD4
- translate.label.attr.clone:
- SMAD4/2524
- Klonalität:
- Monoclonal
- Weitere Details:
- Signaling from the ligand-activated membrane receptor serine/threonine kinases to nuclear targets is mediated by a set of evolutionarily conserved proteins known as DPC4. Upon ligand binding; the receptors of the TGF-alpha family phosphorylate SMAD proteins (SMAD1 and SMAD2). These proteins then move into the nucleus; where they activate transcription. To carry out this function; the receptor activated SMAD1 and 2 require association with the product of deleted in pancreatic carcinoma; locus 4 (DPC4); also known as SMAD4. SMAD4/DPC4 is also implicated as a tumor suppressor; since it is inactivated in more than half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. SMAD4 is absent in approximately 80% of pancreatic adenocarcinoma; but rarely in endometrial; colorectal; ovarian; lung; breast adenocarcinomas; and malignant melanom. SMAD4 is an important marker for confirming a diagnosis of pancreatic adenocarcinoma. Patients with pancreatic adenocarcinomas with SMAD4 protein expression had significantly longer survival than SMAD4 negative patients.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human STAT6 protein
- Isotyp:
- Mouse IgG2a; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg