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Antikörper

Anti-HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) Monoclonal Antibody(Clone: CPTC-HSPD1-1)

Produktgrößen
20 µg
£397,00
36-2509-20UG
100 µg
£716,00
36-2509-100UG
Über dieses Produkt
SKU:
36-2509
Zusätzliche Namen:
60kDa chaperonin; 60kDa heat shock protein mitochondrial; Chaperonin; 60-KD (CPN60); GROEL; HLD4; HSP65; HSPD1; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein; Short heat shock protein 60 Hsp60s1; Spastic paraplegia 13 (SPG13)
translate.label.attr.clone:
CPTC-HSPD1-1
Klonalität:
Monoclonal
Weitere Details:
The heat shock proteins (HSPs) comprise a group of highly conserved; abundantly expressed proteins with diverse functions; including the assembly and sequestering of multiprotein complexes; transportation of nascent polypeptide chains across cellular membranes; and the regulation of protein folding. The mitochondrial and cytosolic localization of HSP60; combined with its binding and catalysis of folding of newly synthesized proteins destined for the mitochondrial matrix; classify this protein as a molecular chaperone. An additional role of HSP 60 is to act as a cell surface marker for T cell recognition; as well as being involved in a danger signal cascade immune response. HSP60 has been shown to influence apoptosis in tumor cells; and changes in its expression level may serve as a biomarker; as down-regulated HSP60 expression indicates a poor prognosis as well as a risk of tumor infiltration development; especially with regard to urothelial carcinomas. In ovarian cancer; decreased expression of HSP60 correlates with aggressive tumor types; while overexpression is correlated with a better patient prognosis.
Host:
Mouse
Immunogen:
Recombinant full-length human HSPD1 protein
Isotyp:
Mouse IgG1; kappa
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig. 2: Formalin-fixed; paraffin-embedded human Breast Carcinoma stained with HSP60 Mouse Monoclonal Antibody (CPTC-HSPD1-1).
Fig. 3: Immunofluorescence Analysis of human MCF-7 cells labeling GPI with HSP60 Mouse Monoclonal Antibody (CPTC-HSPD1-1) followed by Goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red)
Fig. 4: Flow Cytometric Analysis of PFA-fixed HeLa cells labeling HSP60 with HSP60 Mouse Monoclonal Antibody (CPTC-HSPD1-1) followed by Goat anti-Mouse IgG-CF488 (Blue) Isotype Control (Red)
Fig. 4: Flow Cytometric Analysis of PFA-fixed HeLa cells labeling HSP60 with HSP60 Mouse Monoclonal Antibody (CPTC-HSPD1-1) followed by Goat anti-Mouse IgG-CF488 (Blue) Isotype Control (Red)
Fig. 5: Western Blot Analysis of HEP-2 and PC3 cell lysates using HSP60 Mouse Monoclonal Antibody (CPTC-HSPD1-1).