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Antikörper

Anti-APEX Nuclease I Monoclonal Antibody(Clone: CPTC-APEX1-2)

Produktgrößen
20 µg
£397,00
36-2504-20UG
100 µg
£716,00
36-2504-100UG
Über dieses Produkt
SKU:
36-2504
Zusätzliche Namen:
APEX1; AP endonuclease class I; AP lyase; APE; APE-1; APEN; APEX nuclease; Redox factor-1; APX; protein REF-1
translate.label.attr.clone:
CPTC-APEX1-2
Klonalität:
Monoclonal
Weitere Details:
APEX / APE1 is a multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Patients with genetic variants in APEX1 and XRCC1 have been shown to have a higher risk of lung cancer. Elevated APEX1 levels observed in human testicular cancer may be related to relative resistance to therapy and therefore may serve as a diagnostic marker for refractory disease.
Host:
Mouse
Immunogen:
Recombinant human full-length APEX1 protein
Isotyp:
Mouse IgG1; kappa
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
Hersteller:
Abeomics
Typ:
Antibodies:Monoclonal Antibody
  • Datenblatt des Herstellers:1.jpg
Fig. 2: Immunofluorescence Analysis of human HeLa cells labeling APEX Nuclease I with APEX Nuclease I Mouse Monoclonal Antibody (CPTC-APEX1-2) followed by Goat anti-Mouse IgG-CF488 (Green). Phalloidin CF640 stains the membrane red.
Fig. 3: Formalin-fixed; paraffin-embedded human Prostate Carcinoma stained with APEX Nuclease I Mouse Monoclonal Antibody (CPTC-APEX1-2).
Fig. 4: Western Blot Analysis of Human A431; A549; PC3; HAP1; HePG2; cell lysate using APEX Nuclease I Mouse Monoclonal Antibody (CPTC-APEX1-2).
Fig. 4: Western Blot Analysis of Human A431; A549; PC3; HAP1; HePG2; cell lysate using APEX Nuclease I Mouse Monoclonal Antibody (CPTC-APEX1-2).
Fig. 5: Flow Cytometric Analysis of HeLa cells using APEX Nuclease I Mouse Monoclonal Antibody (CPTC-APEX1-2). Goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).