Anti-HLA-DRB (MHC II) Monoclonal Antibody(Clone: L243)
Produktgrößen
20 µg
£397,00
36-2490-20UG
100 µg
£716,00
36-2490-100UG
Über dieses Produkt
- SKU:
- 36-2490
- Zusätzliche Namen:
- DRB1; HLA class II histocompatibility antigen; DR-1 beta chain; HLA-DR-beta 1; HLA-DRB1; human leucocyte antigen DRB1; Leucocyte antigen DR beta 1 chain; lymphocyte antigen DRB1; major histocompatibility complex; class II; DR beta 1; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell su
- translate.label.attr.clone:
- L243
- Klonalität:
- Monoclonal
- Weitere Details:
- This MAb reacts with the HLA-DRB1 antigen; a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. It binds a conformational epitope on HLA-DR; which depends on the correct folding of the heterodimer. This MAb has been reported to block mixed lymphocyte reactions. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody; and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kD alpha (heavy) chain and a 28kD beta (light) chain. It is expressed on B-cells; activated T-cells; monocytes/macrophages; dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules; HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
- Host:
- Mouse
- Immunogen:
- Activated human peripheral blood mononuclear cells
- Isotyp:
- Mouse IgG2a; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg