Anti-HLA-DQ (MHC II) Monoclonal Antibody(Clone: rSPV-L3)
Produktgrößen
20 µg
£397,00
36-2484-20UG
100 µg
£716,00
36-2484-100UG
Über dieses Produkt
- SKU:
- 36-2484
- Zusätzliche Namen:
- CELIAC1; DC 4 alpha chain Gluten sensitive enteropathy (celiac disease) (GSE); HLA class II histocompatibility antigen DQ(1) alpha chain; HLA class II histocompatibility antigen DQ(3) alpha chain; IDDM1; Leucocyte antigen DQA1; Major histocompatibility complex class II DQ alpha 1 (HLA DQA1); Major h
- translate.label.attr.clone:
- rSPV-L3
- Klonalität:
- Monoclonal
- Weitere Details:
- Recognizes a DQ antigen; which is a dimer of 60kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB); both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes; dendritic cells; macrophages). The alpha chain is approximately 33-35kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities; resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones.
- Host:
- Mouse
- Immunogen:
- T4-positive CTL clone HG-38
- Isotyp:
- Mouse IgG1; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php