Anti-PD-L1 / PDCD1LG1 / CD274 / B7-H1 (Cancer Immunotherapy Target) Monoclonal Antibody(Clone: PDL1/2744)
Produktgrößen
20 µg
£397,00
36-2429-20UG
100 µg
£716,00
36-2429-100UG
Über dieses Produkt
- SKU:
- 36-2429
- Zusätzliche Namen:
- B7 homolog 1; B7-H1; CD274; PD-L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; Programmed cell death 1 ligand 1
- translate.label.attr.clone:
- PDL1/2744
- Klonalität:
- Monoclonal
- Weitere Details:
- Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T-cell proliferation; cytokine production; differentiation of effector T-cells and the induction of BCLX; a promoter of T-cell survival. Engagement of CTLA4 by B7-1 or B7-2; on the other hand; may inhibit proliferation and interleukin-2 (IL-2) production. PD-L1 is 290-amino acid type I transmembrane protein; which is 20% and 15% identical to B7-1 and B7-2; respectively; has immunoglobulin V-like and C-like domains and a 30-amino acid cytoplasmic tail. PD-L1 does not bind CD28; cytotoxic T-lymphocyte A4 or ICOS (inducible co-stimulator). IL-2; althoµgh produced in small amounts; is required for the effect of PD-L1 co-stimulation. PD-L2 protein contains a signal sequence; IgV- and IgC-like domains; a transmembrane region and a cytoplasmic region. The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart; lung and kidney sµggests that the PD-1-PD-L system could provide unique negative signaling to help prevent autoimmune diseases.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human CD274 protein (around aa39-191) (exact sequence is proprietary)
- Isotyp:
- Mouse IgG1; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
