Anti-Blood Group Antigen A (CD173) Monoclonal Antibody(Clone: HE-14)
Produktgrößen
20 µg
£397,00
36-2403-20UG
100 µg
£716,00
36-2403-100UG
Über dieses Produkt
- SKU:
- 36-2403
- Zusätzliche Namen:
- A transferase; ABO; B transferase; CD173; Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; Histo-blood
- Anwendung:
- Agglutination
- translate.label.attr.clone:
- HE-14
- Klonalität:
- Monoclonal
- Weitere Details:
- This antibody recognizes human blood group A (monofucosyl and difucosyl A antigens with chain types 1; 2; 3; 4; 5; 6) and Forssmann antigen. It is also reactive with the immuno-dominant A trisaccharide. Blood group antigen expression in human colon cancer was studied by means of two monoclonal antibodies of broad anti-A (HE-14) and anti-type 3 and type 4 chain-based A and H (HE-10) specificity. These antigens were proved to re-appear in tumors of the distal colon; the HE-10 antibody reacting more frequently (9 out of 12 samples) than HE-14 (5 out of 12 samples) and frequently with supra-nuclear staining of the cytoplasm probably in those places of the Golgi apparatus where carbohydrate antigens are synthesized. This staining pattern is characteristic of HE-10 in normal colonic mucosa as well. With HE-14; staining was often absent in less differentiated tumors; while HE-10 did react in such tumors. In some cases; these two antibodies gave different staining patterns in parallel sections from the same tissue sample; primarily at the cellular level. Three out of 12 cases showed blood group antigen expression in the mucosa of the distal colon adjacent to the tumor only when HE-10 Ab was used.
- Host:
- Mouse
- Immunogen:
- Mixture of erythrocytes of blood group A1and glyco protein fraction isolated from the saliva of secretors with blood group A
- Isotyp:
- Mouse IgM; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php