Anti-Ferritin; Heavy Chain (FTH) (Microglia Marker) Monoclonal Antibody(Clone: FTH/2081)
Produktgrößen
20 µg
£397,00
36-2337-20UG
100 µg
£716,00
36-2337-100UG
Über dieses Produkt
- SKU:
- 36-2337
- Zusätzliche Namen:
- Apoferritin; Cell proliferation-inducing gene 15 protein; Ferritin H subunit; Ferritin heavy chain; FHC; FRIH; FTH1; FTHL6; Iron overload autosomal dominant; PIG15; Placenta immunoregulatory factor; Proliferation inducing gene 15 protein (PLIF)
- translate.label.attr.clone:
- FTH/2081
- Klonalität:
- Monoclonal
- Weitere Details:
- Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains; ferritin heavy chain and ferritin light chain; which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage; the oxidationof FeI(II); whereas ferritin light chains promote the nucleation of ferrihydrite; enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering; heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase; which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome; in which light chain ferritin is overexpressed; and oxidative stress; an important factor in the development of aging-related cataracts.
- Host:
- Mouse
- Immunogen:
- Recombinant human FTH1 protein fragment (around aa 58-180) (exact sequence is proprietary)
- Isotyp:
- Mouse IgG2c; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
