Anti-ALK (Anaplastic Lymphoma Kinase) / CD246 Monoclonal Antibody(Clone: ALK/1504)
Produktgrößen
20 µg
£397,00
36-2328-20UG
100 µg
£716,00
36-2328-100UG
Über dieses Produkt
- SKU:
- 36-2328
- Zusätzliche Namen:
- ALK Tyrosine Kinase Receptor; ALK/NPM1 fusion gene; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; anaplastic lymphoma receptor tyrosine kinase; CD246; mutant anaplastic lymphoma kinase; NBLST3; Tcrz; TFG/ALK
- translate.label.attr.clone:
- ALK/1504
- Klonalität:
- Monoclonal
- Weitere Details:
- The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons; and a few endothelial cells and pericytes. The hybrid gene;NPM-ALK; created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein; nucleophosmin (NPM); joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence; the ALK gene comes under the control of the NPM promoter; which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene; resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly; expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control.
- Host:
- Mouse
- Immunogen:
- Recombinant human ALK protein fragment (aa200-335)
- Isotyp:
- Mouse IgG2b; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
