Anti-ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) Monoclonal Antibody(Clone: ICOSL/3260)
Produktgrößen
20 µg
£397,00
36-2304-20UG
100 µg
£716,00
36-2304-100UG
Über dieses Produkt
- SKU:
- 36-2304
- Zusätzliche Namen:
- B7 homolog 2 (B7H2); B7 like protein Gl50; B7 related protein 1 (B7RP1); CD275; CD275 antigen; GL50; ICOS LG; ICOS ligand (ICOSL); Inducible T cell co stimulator ligand; LICOS; Transmembrane protein B7 H2 ICOS ligand
- translate.label.attr.clone:
- ICOSL/3260
- Klonalität:
- Monoclonal
- Weitere Details:
- This MAb recognizes a protein of 36kDa; identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes; and by Northern blot there are 2.4; 3.0; and 7.0 kb transcripts in brain; heart; kidney; and liver; with lower expression in colon and thymus; and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF); granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human ICOSLG (B7RP-1) protein (around aa 23-149) (exact sequence is proprietary)
- Isotyp:
- Mouse IgG2b; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
