Anti-CD16 / FcγReceptor III Monoclonal Antibody(Clone: HuNK2)
Produktgrößen
20 µg
£397,00
36-2283-20UG
100 µg
£716,00
36-2283-100UG
Über dieses Produkt
- SKU:
- 36-2283
- Zusätzliche Namen:
- FcRIIIa; FCR-10; FcRIII; FCGRIII; FcR-10; Fc fragment of IgG; low affinity IIIa; receptor for (CD16); neutrophil-specific antigen NA; CD16a; low affinity immunoglobulin gamma Fc region receptor III-A; Fc-gamma RIIIa; immunoglobulin G Fc receptor III; Fc-gamma RIII-alpha; Fc-gamma receptor IIIb (CD16
- translate.label.attr.clone:
- HuNK2
- Klonalität:
- Monoclonal
- Weitere Details:
- It recognizes CD16 (FcgammaRIII); the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. Two similar genes represent CD16; CD16A (FcgammaRIIIA); which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcgammaRIIIB); which exist as a monomeric GPI-anchored form in neutrophils. Furthermore; there are two known polymorphisms of CD16B; NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding; both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC); phagocytosis; degranulation and proliferation.
- Host:
- Mouse
- Immunogen:
- Human peripheral blood lymphocytes from a NK-leukemia patient.
- Isotyp:
- Mouse IgG2a; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg