Anti-HER-4 / ERBB4 Monoclonal Antibody(Clone: ERBB4/2581)
Produktgrößen
20 µg
£397,00
36-2237-20UG
100 µg
£716,00
36-2237-100UG
Über dieses Produkt
- SKU:
- 36-2237
- Zusätzliche Namen:
- Avian erythroblastic leukemia viral oncogene homolog 4; HER4; human epidermal growth factor receptor 4; p180erbB4; Proto-oncogene-like protein c-ErbB-4
- translate.label.attr.clone:
- ERBB4/2581
- Klonalität:
- Monoclonal
- Weitere Details:
- The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1); Neu (ErbB-2; HER2); ErbB-3 (HER3) and ErbB-4 (HER4); which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein; which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines; normal skeletal muscle; heart; pituitary; brain and cerebellum. Its expression in breast cancer; pediatric brain cancer and other types of carcinomas has been reported in studies which sµggest ErbB4 expression is involved in both normal tissue development and carcinogenesis.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 1116-1269) of human ERBB4 (HER4) protein (exact sequence is proprietary)
- Isotyp:
- Mouse IgG1; kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Antibody with azide - store at 2 to 8[o]C. Antibody without azide - store at -20 to -80[o]C. Antibody is stable for 24 months. Non-hazardous.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:1.jpg
